Some studies do not report back significant improvements in insulin sensitivity have used 50mg daily for 3 months in otherwise healthy overweight aged men with low (less than 1500ng/mL) DHEA; DHEA did not even trend towards significance, and appeared to have no directional effect.  This lack of efficacy resulting in no trend towards significance has been noted elsewhere with doses that should normally work.   In post-menopausal women where DHEA would not show efficacy, the combination of DHEA and mixed exercises did not create efficacy of DHEA. 
The labels claim DHEA will help us lose weight , rev up our libido, lift depression and give us back the strength, immunity, and stamina we had when we were 20 — the age at which our bodies naturally produced the most DHEA. While on the surface this is appealing (who wouldn’t want to feel 20 again?), it’s obviously not what nature intended. We also don’t know enough about DHEA to be conducting such a large, unregulated public experiment. DHEA is a potent steroid — that’s why it made headlines and why it should be approached with due diligence.
DHEA (dehydroepiandosterone) is a potent hormone produced naturally by the adrenal glands. It is converted in the body to both the female hormone estrogen and the male hormone testosterone. Levels of DHEA decline naturally with age and in cases of a condition known as adrenal insufficiency. Because both older people with a natural decline and people with adrenal insufficiency notice a drop in libido, several studies have examined whether supplemental DHEA can improve libido in these groups. Preliminary research suggests that it may help improve sexual function in women, although well-controlled studies are needed.