The labels claim DHEA will help us lose weight , rev up our libido, lift depression and give us back the strength, immunity, and stamina we had when we were 20 — the age at which our bodies naturally produced the most DHEA. While on the surface this is appealing (who wouldn’t want to feel 20 again?), it’s obviously not what nature intended. We also don’t know enough about DHEA to be conducting such a large, unregulated public experiment. DHEA is a potent steroid — that’s why it made headlines and why it should be approached with due diligence.
DHEA is transformed into DHEA-S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1 .    This occurs naturally in the adrenal cortex and during first-pass metabolism in the liver and intestines when exogenous DHEA is administered orally. [ citation needed ] Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA.  DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS).