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The ACC recognized that clinicians and patients may seek firmer and more specific guidance on the adequacy of statin therapy and whether or when to use non-statin therapies if response to statins is deemed inadequate. Therefore, the ACC convened this expert consensus decision pathway writing committee to address current gaps in care for LDL-C lowering to reduce ASCVD risk. This effort relies extensively on the evidence base established by the 2013 ACC/AHA cholesterol guideline and attempts to provide further recommendations for clinicians and patients regarding use of non-statin therapies. It should be noted that this process did not involve formal systematic reviews, grading of evidence, or synthesis of evidence. The goal was to provide practical guidance for clinicians and patients in situations not covered by the 2013 ACC/AHA guideline until such time as the next round of guidelines has the opportunity to formally review recent scientific evidence and cardiovascular outcomes trials are completed with new agents for ASCVD risk reduction. Specifically, this panel was convened by the ACC to answer the following questions regarding use of non-statin therapies:

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