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Subsidies and financial assistance are given for drugs approved under the Standard Drug List (SDL) and Medication Assistance Fund (MAF). Drugs approved under the SDL and MAF must be registered with the Health Sciences Authority (HSA) and assessed to be clinically- and cost-effective. MAF drugs are generally newer and more expensive, and therefore MAF applies only when these drugs are used for suitable clinical indications so that MAF drugs are appropriately used. In exceptional cases, MAF can also support HSA-registered drugs that are not on the SDL or MAF list, on a case-by-case basis.

Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul . Guggulsterone can exist as either of two stereoisomers , E -guggulsterone and Z -guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor , which was once believed to result in decreased cholesterol synthesis in the liver . Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein ("bad cholesterol") increased in many people. [1] [2] Nevertheless, guggulsterone is an ingredient in many nutritional supplements .

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