So we know we don't want to go too low with estradiol or we could end up with brittle bones and hip fractures like a lot of 75 year old women struggle with. Furthermore, common sense dictates that more is not better when it comes to estradiol. Many men who go on HRT and end up with estradiol in the 40's and 50's very commonly have a certain suite of side effects: gyno, water retention, lowered libido, loss of erectile strength, moodiness, poor sleep etc. If you've been around Peak Testosterone Forum at all, you know this is actually quite common. And many experts have concern about long term effects as well, because high estradiol may increase clotting risk, arterial plaque and prostate issues as I mentioned.
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So, how does one ensure that testosterone levels remain in balance? Some doctors suggest that monitoring testosterone levels every five years, starting at age 35, is a reasonable strategy to follow. If the testosterone level falls too low or if the individual has the signs and symptoms of low testosterone levels described above, testosterone therapy can be considered. However, once testosterone therapy is initiated, testosterone levels should be closely monitored to make sure that the testosterone level does not become too high, as this may cause stress on the individual, and high testosterone levels may result in some of the negative problems (described previously) seen.