Progestins are steroid hormones that are typically prescribed to postpone heat cycles or alleviate false pregnancies in female dogs and treat benign prostatic hypertrophy in male dogs. They may also be used for some types of skin problems or to modify aggressive behavior. Megestrol acetate and medroxyprogesterone are the most commonly used progestins in dogs. Potential side effects include increased thirst and appetite, behavioral changes, mammary gland enlargement, and an increased likelihood of developing diabetes mellitus, acromegaly (a hormonal disease that causes enlargement of the head), Cushing’s disease, uterine infection (pyometra), reproductive disorders, and some types of cancer.
Stephan Bonnar and Josh Barnett , mixed martial arts (MMA) fighters from the UFC and PRIDE Fighting Championships , have also tested positive for the banned substance.  After the World Extreme Cagefighting show on January 20, 2006 Muay Thai turned MMA fighter Kit Cope also tested positive for boldenone.  Following the Strikeforce card on June 22, 2007 former PRIDE and UFC fighter Phil Baroni tested positive for boldenone, as well as stanozolol .  At a K-1 WGP event in Las Vegas on August 17, 2007 two fighters, Rickard Nordstrand and Zabit Samedov , both tested positive for boldenone.  Alexandre Franca Nogueira tested positive for boldenone in July 2008. 
When a follow up investigation is needed, laboratory reports/results ( . from a QMPI importer) should be forwarded to a CFIA inspector.
The CFIA Inspector will communicate with their respective Regional/Area Program Staff who will liase with the National Manager Technical Standards (or delegate), Fish, Seafood and Production Division. The follow up investigation approach may include, but not limited to gathering evidence of non-deliberate use, collecting and reviewing additional information, etc. , for an assessment and this will be determined on a case-by-case basis.